Bionanocomposites, Biomaterials & DDS

Research

Works that have been done so far:

 

The preparation, processing and characterization of biodegradable monofilament suture based on L-Lactide/Glycolide/Trimethylene carbonate (TMC)

Preparation of antibacterial nano-biocomposites based on PLLA for medical applications

1- Synthesis and characterization of Poly L-Lactic acid (PLLA) in two different molecular weights

2- Encapsulation of antibacterial Triclosan using nano PLLA (PLA120)

3- Preparation of composites based on PLA0 and optimized nanodrug (LATC30)

4- Nanocomposites based on PLA0, LATC30 and nano hydroxyapatite (nHA)

In order to make Bionanocomposites we can use this simple figure

1- LATC30 imparted antibacterial properties
2- Establishing interactions between –Cl groups of triclosan and ester groups of PCL

Interfacial affinity between hydrophilic starch and hydrophobic polyesters improved

Melt Electrospinning

Skin tissue Engineering

Composite Blends Based on PLA/PCL and Silk

Injectable PNIPAM/Hyaluronic acid hydrogels containing modified particles for cartilage tissue engineering

Double-crosslinking hyaluronic acid hydrogels containing PLGA/dexamethasone nanoparticles for medical applications

Anti Adhesion Applications????

Chitosan/Agarose/ECM for nasal cartilage tissue engineering

Chitosan/PVP hydrogel scaffolds with PLGADEX microparticles

Treatment of chronic rhinosinusitis

Chitosan/Alginate/hesperidin for treatment of skin injuries and wound healing

  • Hyaluronic acid (HA) and chitosan (CH) derivatives with opposite charges was used for hydrogels.
  • To increase the interaction between them phenol moieties were substituted on the backbone of HA (HAPH) and CH (CHPH) via carbodiimide-mediated condensation reaction
  • Then subjected to enzymatic cross-linking in the presence of horseradish peroxidase
  • Creation of stable hybrid microenvironment for cell encapsulation and tissue engineering

 

Peer Reviewed Publications:

    1. S.M. Davachi, B. Kaffashi, International Journal of Polymeric Materials and Polymeric Biomaterials 2015, 64, 10, 497 – 508.
    2. S.M. Davachi, B. Kaffashi, A. Zamanian, B. Torabinejad, Z. Ziaeirad, Material Science & Engineering C 2016, 58, 294–309
    3. S.M. Davachi, B. Kaffashi, B. Torabinejad, A. Zamanian, Polymer 2016, 83, 101-110
    4. S.M. Davachi, B. Kaffashi, B. Torabinejad, A. Zamanian, J. Seyfi, I. Hejazi, Polymer 2016, 90, 232-241
    5. S.M. Davachi, B. Kaffashi, “Poly Lactic Acid in Medicine”, Review Article, Polymer-Plastics Technology and Engineering 2015, 54, 9, 944-967.
    6. S. Davoodi, E. Oliaei, S.M. Davachi, I. Hejazi, J. Seyfi, B.S. Heidari, H. Ebrahimi, ” RSC Advances 2016, 6, 39870–39882
    7. S.M. Davachi, B.S. Heidari, I. Hejazi, J. Seyfi, E. Oliaei, A. Farzaneh, H. Rashedi, Carbohydrate Polymers 2017, 155, 336-344
    8. S Balali, S.M. Davachi, R Sahraeian, B.S. Heidari, J Seyfi, I Hejazi, Biomacromolecules 2018, 19 (11), 4358-4369
    9. B.S. Heidari, P. Chen, R. Rui, S.M. Davachi, Hani Al-Salami, E. De Juan Pardo, M. Zheng, B. Doyle, Journal of Materials Chemistry B 2021, 9, 10, 2532-2546
    10. B.S. Heidari, E.M. Lopez, P. Chen, R. Ruan, E. Vahabli, S.M. Davachi, F. Granero-Moltó, E.M. De-Juan-Pardo, M. Zheng, B. Doyle, Materials Today Bio 2023, 22, 100778
    11. B.S. Heidari, E.M. Lopez, E. Harrington, R. Ruan, P. Chen, S.M. Davachi, B. Allardyce, R. Rajkhowa, R. Dilley, F. Granero-Moltó, Bioactive Materials 2023, 25, 291–306
    12. Z. Atoufi, S.K. Kamrava, S.M. Davachi, M. Hassanabadi, S. Saeedi Garakani, R. Alizadeh, M. Farhadi, S. Tavakol, Z. Bagher, G. Hashemi Motlagh, International Journal of Biological Macromolecules 2019, 139, 1168-118
    13. Z. Mousavi Nejad, B. Torabinejad, S.M. Davachi, A. Zamanian, S. Saeedi Garakani, F. Najafi, N. Nezafati, International Journal of Biological Macromolecules 2019, 12, 193-208
    14. S. Saeedi Garakani, M. Khanmohammadi, Z. Atoufi, S.K. Kamrava, M. Setayeshmehr, R. Alizadeh, F. Faghihi, Z. Bagher, S.M. Davachi, A. Abbaspourrad, International Journal of Biological Macromolecules 2020, 143, 533-545.
    15. S. Saeedi Garakani, S.M. Davachi, Z. Bagher, A. Heraji Esfahani, N. Jenabi, Z. Atoufi, M. Khanmohammadi, A. Abbaspourrad, H. Rashedi, M. Jalessi, International Journal of Biological Macromolecules 2020, 164, 356-370.
    16. Z. Bagher, A. Ehterami, H. Semiari, A. Asefnejad, S.M. Davachi, Mehdi Mirzaii, Majid Salehi, Journal of Drug Delivery Science and Technology 2020, 55, 101379
    17. S.M. Davachi, S.M.A. Haramshahi, S.A. Akhavirad, N. Bahrami, S. Hassanzadeh, S. Ezzatpour, N. Hassanzadeh, M. Malekzadeh Kebria, M. Khanmohammadi, Z. Bagher, Materials Today Communications 30 (2022) 103230.